Administración y detección eficaz de fármacos por medio de dispositivos nanoestructurados tipo jaula: estudios teóricos y perspectivas
Resumen
Este artículo de revisión presenta el panorama actual del estudio de nanomateriales para aplicaciones relacionadas con la administración y detección de fármacos. Debido a los grandes avances en la fabricación y síntesis de nanomateriales, desde hace algunas décadas, estos sistemas aplicados al campo biomédico han constituido una revolución. En específico y debido a sus extraordinarias características fisicoquímicas, el estudio de pequeñas nanoestructuras con geometrías de jaulas cerradas de 24 átomos ha sido la motivación de un intenso trabajo desde la ciencia básica. Más aún, de entre las diversas potenciales áreas tecnológicas, estos sistemas han sido recurrentemente propuestos en aplicaciones relacionadas con la administración y detección de fármacos. Este trabajo de revisión se enfoca en los hallazgos teóricos más relevantes obtenidos por metodologías computacionales y más precisamente utilizando la teoría de funcionales de la densidad (TFD). El estudio de estos nanomateriales por métodos computacionales TDF ha constituido una estrategia exitosa, pues ha ayudado a mejorar el diseño de estos y a evaluar sus diversas propiedades. Estos hallazgos teóricos han guiado la síntesis y aplicación en sistemas biológicos reales.
Citas
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