Una revisión de nanopartículas de oro: características fisicoquímicas y su respuesta celular en macrófagos
Resumen
El estudio de los nanomateriales (NMs) y sus propiedades fisicoquímicas como tamaño, naturaleza química, composición y forma es de suma importancia. Específicamente las nanopartículas de oro (AuNPs) y sus formas como rodillos, esferas y cubos son utilizados en el ámbito biomédico; por ejemplo, las nanoestrellas y cubos de oro presentan un gran efecto de resonancia del plasmón de superficie localizador (LSPR), permitiendo ser utilizadas en diagnóstico, marcaje y terapias tumorales; sin embargo, estos últimos carecen o tienen pocos estudios toxicológicos in vitro que permiten asegurar su biocompatibilidad. En esta revisión se mencionan las principales características de las AuNPs que permiten usarlas en estas terapias y algunos de los estudios celulares realizados con ellas en cultivos de macrófagos para la obtención de concentraciones adecuadas y su futura aplicación médica.
Citas
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